About
gluconeogenesis, the diabetic "Whack A Mole" challenge ...
Re:
https://www.ruled.me/what-is-gluconeogenesis/
"What is Gluconeogenesis?"
Re:
https://pubmed.ncbi.nlm.nih.gov/9416027/
"Protein: metabolism and effect on blood glucose levels"
"with insulin deficiency,
gluconeogenesis proceeds rapidly and contributes to an elevated blood glucose level"
Re:
https://accessmedicine.mhmedical.com/co ... d=73243720
"CHAPTER 19: Gluconeogenesis & the Control of Blood Glucose"
This now suggests that a very low carb diet is not good for diabetics because insufficient insulin results in
gluconeogenesis
(body starts getting glucose from non-carb sources), thus causing higher than normal blood sugar
The Goldilocks solution to gluconeogenesis?
Sufficient carbs per meal, with balanced protein, fat, carbs
(and not quick-digesting carbs!).
Long story short ...
Gluconeogenesis is evolutionary safeguard to make sure the brain has fuel (glucose) during periods of starvation or fasting.
This becomes a problem for diabetics and pre-diabetics because their insulin may be insufficient to help regulate gluconeogenesis
(thus cause higher blood sugar from non-carb sources).
Related info about carbs ...
Re:
https://www.youtube.com/watch?v=uR2ksqDy5os
"REVERSE Type 2 Diabetes in 5 Easy Steps"
Dr. Ken Berry, a Keto Diet promoter, is VERY knowledgeable about diabetes and has 100s of videos online.
This video's tips: Stop eating sugar, grains, and below ground veggies (all high in carbohydrates).
More videos to prove that Dr. Berry knows about diabetes:
Re:
https://www.youtube.com/watch?v=uAijPglN_I0
"7 Fruits Diabetics should AVOID"
Re:
https://www.youtube.com/watch?v=Am1urVNSseY
"5 Best/Worst Breakfasts for Diabetics"
"Eat bacon!" This tip effectively cautions that avoiding high-carbohydrate foods (or portions)
is the better rule of thumb than Dr. Berry's recommended foods. However, Dr. Berry does mention
that a glucometer helps identify foods that are a person's glucose troublemakers.
More info about gluconeogenesis ...
Re:
https://www.quora.com/When-does-glucone ... r-14-hours
"When does gluconeogenesis occur during fasting, after 8 hours or after 14 hours?"
"Gluconeogenesis in the liver depends upon signals of lowered circulating levels of blood glucose. The rate of decline in circulating blood glucose levels from fasting (i.e. not eating) sufficient to trigger gluconeogenesis varies among individuals due to levels of fitness, adipose tissue body percentages and the health of one’s liver. In healthy individuals (i.e. non-diabetics, no metabolic syndrome, etc.) who are leading an historically normal lifestyle of not eating late at night and having a fairly active day (i.e. non-sedentary), gluconeogenesis happens regularly overnight prior to break-fast, or breaking of the evening fast since their last meal at a traditional hour (except for Spain), i.e 6 to 7 pm.
This means gluconeogenesis occurs regularly, on average, for normal lifestyles and healthy constitutions at about the 10 to 12 hour fasting mark."
See also:
https://my.clevelandclinic.org/health/a ... 3-glucagon
"What is glucagon?"
"Both hormones come from your pancreas — alpha cells in your pancreas make and release glucagon, and beta cells in your pancreas make and release insulin. The difference is in how these hormones contribute to blood sugar regulation. Glucagon increases blood sugar levels, whereas insulin decreases blood sugar levels."
Analysis: Since insulin presence downregulates gluconeogenesis (glucagon upregulates gluconeogenesis), insufficient insulin might cause unbalanced gluconeogenesis (even earlier) in a bedtime fast. This hints, IMO, that carb digestion should be slow and just sufficient during the 12 hour period which includes the bedtime fast. Now, a light, nutritionally balanced bedtime snack comes to mind! In other words, the snack's carbs should be limited to the body's available insulin ... and this applies to all meals of the diabetic and pre-diabetic. Who knew?!
Rod